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'''Unreleased structure'''


The entry 8eom is ON HOLD
==TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973==
 
<StructureSection load='8eom' size='340' side='right'caption='[[8eom]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
Authors: The, J., Hong, Z., Headey, S., Gunzburg, M., Doak, B., James, L.I., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8eom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EOM FirstGlance]. <br>
Description: TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=WNQ:4-(4-methylpiperazine-1-sulfonyl)benzamide'>WNQ</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eom OCA], [https://pdbe.org/8eom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eom RCSB], [https://www.ebi.ac.uk/pdbsum/8eom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eom ProSAT]</span></td></tr>
[[Category: Gunzburg, M]]
</table>
[[Category: James, L.I]]
== Disease ==
[[Category: Arrowsmith, C.H]]
[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
[[Category: Brown, P.J]]
== Function ==
[[Category: Edwards, A.M]]
[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
[[Category: Headey, S]]
== References ==
[[Category: Hong, Z]]
<references/>
[[Category: The, J]]
__TOC__
[[Category: Structural Genomics Consortium (Sgc)]]
</StructureSection>
[[Category: Doak, B]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Brown PJ]]
[[Category: Doak B]]
[[Category: Edwards AM]]
[[Category: Gunzburg M]]
[[Category: Headey S]]
[[Category: Hong Z]]
[[Category: James LI]]
[[Category: The J]]
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