1h2p: Difference between revisions

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[[Image:1h2p.gif|left|200px]]<br />

[[Image:1h2p.gif|left|200px]]<br /><applet load="1h2p" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1h2p" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1h2p, resolution 2.8Å" />

'''HUMAN CD55 DOMAINS 3 & 4'''<br />

==Overview==

Decay-accelerating factor (CD55), a regulator of the alternative and, classical pathways of complement activation, is expressed on all, serum-exposed cells. It is used by pathogens, including many enteroviruses, and uropathogenic Escherichia coli, as a receptor prior to infection. We, describe the x-ray structure of a pathogen-binding fragment of human CD55, at 1.7 A resolution containing two of the three domains required for, regulation of human complement. We have used mutagenesis to map biological, functions onto the molecule; decay-accelerating activity maps to a single, face of the molecule, whereas bacterial and viral pathogens recognize a, variety of different sites on CD55.

Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.

==Disease==

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==About this Structure==

1H2P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1H2P OCA].

1H2P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H2P OCA].

==Reference==

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[[Category: Billington, J.]]

[[Category: Chaudhry, Y.]]

[[Category: Evans, D.J.]]

[[Category: Evans, D J.]]

[[Category: Goodfellow, I.]]

[[Category: Lea, S.M.]]

[[Category: Lea, S M.]]

[[Category: Spiller, B.]]

[[Category: Williams, P.]]

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[[Category: ligand for cd97]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 17:12:~~12 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:56:42 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1h2p.gif|left|200px]]<br />
+[[Image:1h2p.gif|left|200px]]<br /><applet load="1h2p" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1h2p" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1h2p, resolution 2.8&Aring;" />
 '''HUMAN CD55 DOMAINS 3 & 4'''<br />
 ==Overview==
-Decay-accelerating factor (CD55), a regulator of the alternative and, classical pathways of complement activation, is expressed on all, serum-exposed cells. It is used by pathogens, including many enteroviruses, and uropathogenic Escherichia coli, as a receptor prior to infection. We, describe the x-ray structure of a pathogen-binding fragment of human CD55, at 1.7 A resolution containing two of the three domains required for, regulation of human complement. We have used mutagenesis to map biological, functions onto the molecule; decay-accelerating activity maps to a single, face of the molecule, whereas bacterial and viral pathogens recognize a, variety of different sites on CD55.
+Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-H2P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H2P OCA].
+H2P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H2P OCA].
 ==Reference==
@@ Line 19: / Line 18: @@
 [[Category: Billington, J.]]
 [[Category: Chaudhry, Y.]]
-[[Category: Evans, D.J.]]
+[[Category: Evans, D J.]]
 [[Category: Goodfellow, I.]]
-[[Category: Lea, S.M.]]
+[[Category: Lea, S M.]]
 [[Category: Spiller, B.]]
 [[Category: Williams, P.]]
@@ Line 32: / Line 31: @@
 [[Category: ligand for cd97]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:12:12 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:56:42 2008''