1iox: Difference between revisions

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[[Image:1iox.gif|left|200px]]
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[[Image:1iox.png|left|200px]]


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{{STRUCTURE_1iox|  PDB=1iox  |  SCENE=  }}  
{{STRUCTURE_1iox|  PDB=1iox  |  SCENE=  }}  


'''NMR Structure of human Betacellulin-2'''
===NMR Structure of human Betacellulin-2===




==Overview==
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The solution structure of the EGF-like domain of betacellulin (BTCe), a newly discovered member of the epidermal growth factor (EGF) family, has been determined using two-dimensional nuclear magnetic resonance spectroscopy. This is the first report to identify the solution structure of the EGF-family ligand monomers that interact with both ErbB-1 and ErbB-4. The solution structure of BTCe was calculated using 538 NMR-derived restraints. The overall structure of BTCe was stabilized by three disulfide bonds, a hydrophobic core, and 23 hydrogen bonds. It appears that BTCe is comprised of five beta-strands and one short 3(10) helical turn. The secondary structural elements of BTCe are basically similar to those of the other EGF-family proteins, except that several significant variations of the structural properties were found. It is suggested that the structural variations between BTCe and the other EGF-family ligands may affect the specific receptor-recognition properties of EGF-family ligands.
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{{ABSTRACT_PUBMED_12074582}}


==About this Structure==
==About this Structure==
1IOX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOX OCA].  
1IOX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOX OCA].  


==Reference==
==Reference==
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[[Category: Yamada, H.]]
[[Category: Yamada, H.]]
[[Category: Egf-like fold]]
[[Category: Egf-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:43:31 2008''

Revision as of 10:43, 1 July 2008

File:1iox.png

Template:STRUCTURE 1iox

NMR Structure of human Betacellulin-2

Template:ABSTRACT PUBMED 12074582

About this Structure

1IOX is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of betacellulin, a new member of EGF-family ligands., Miura K, Doura H, Aizawa T, Tada H, Seno M, Yamada H, Kawano K, Biochem Biophys Res Commun. 2002 Jun 28;294(5):1040-6. PMID:12074582

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