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| [[Image:1iqv.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1iqv| PDB=1iqv | SCENE= }} | | {{STRUCTURE_1iqv| PDB=1iqv | SCENE= }} |
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| '''Crystal Structure Analysis of the archaebacterial ribosomal protein S7'''
| | ===Crystal Structure Analysis of the archaebacterial ribosomal protein S7=== |
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| ==Overview==
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| Ribosomal protein S7 is one of the ubiquitous components of the small subunit of the ribosome. It is a 16S rRNA-binding protein positioned close to the exit of the tRNA, and it plays a role in initiating assembly of the head of the 30S subunit. Previous structural analyses of eubacterial S7 have shown that it has a stable alpha-helix core and a flexible beta-arm. Unlike these eubacterial proteins, archaebacterial or eukaryotic S7 has an N-terminal extension of approximately 60 residues. The crystal structure of S7 from archaebacterium Pyrococcus horikoshii (PhoS7) has been determined at 2.1 A resolution. The final model of PhoS7 consists of six major alpha-helices, a short 3(10)-helix and two beta-stands. The major part (residues 18-45) of the N-terminal extension of PhoS7 reinforces the alpha-helical core by well-extended hydrophobic interactions, while the other part (residues 46-63) is not visible in the crystal and is possibly fixed only by interacting with 16S rRNA. These differences in the N-terminal extension as well as in the insertion (between alpha1 and alpha2) of the archaebacterial S7 structure from eubacterial S7 are such that they do not necessitate a major change in the structure of the currently available eubacterial 16S rRNA. Some of the inserted chains might pass through gaps formed by helices of the 16S rRNA.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11686933}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11686933 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11686933}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ribosomal protein]] | | [[Category: Ribosomal protein]] |
| [[Category: Rna-binding]] | | [[Category: Rna-binding]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:18:08 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:50:09 2008'' |
