1ir6: Difference between revisions

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[[Image:1ir6.jpg|left|200px]]
{{Seed}}
[[Image:1ir6.png|left|200px]]


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{{STRUCTURE_1ir6|  PDB=1ir6  |  SCENE=  }}  
{{STRUCTURE_1ir6|  PDB=1ir6  |  SCENE=  }}  


'''Crystal structure of exonuclease RecJ bound to manganese'''
===Crystal structure of exonuclease RecJ bound to manganese===




==Overview==
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RecJ, a 5' to 3' exonuclease specific for single-stranded DNA, functions in DNA repair and recombination systems. We determined the crystal structure of RecJ bound to Mn(2+) ion essential for its activity. RecJ has a novel fold in which two domains are interconnected by a long helix, forming a central groove. Mn(2+) is located on the wall of the groove and is coordinated by conserved residues characteristic of a family of phosphoesterases that includes RecJ proteins. The groove is composed of residues conserved among RecJ proteins and is positively charged. These findings and the narrow width of the groove indicate that the groove binds single- instead of double-stranded DNA.
The line below this paragraph, {{ABSTRACT_PUBMED_11972066}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11972066}}


==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Two domains interconnected by alpha-helix]]
[[Category: Two domains interconnected by alpha-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:18:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:51:12 2008''

Revision as of 10:51, 1 July 2008

File:1ir6.png

Template:STRUCTURE 1ir6

Crystal structure of exonuclease RecJ bound to manganese

Template:ABSTRACT PUBMED 11972066

About this Structure

1IR6 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity., Yamagata A, Kakuta Y, Masui R, Fukuyama K, Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5908-12. Epub 2002 Apr 23. PMID:11972066

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