1h6i: Difference between revisions
New page: left|200px<br /> <applet load="1h6i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h6i, resolution 3.54Å" /> '''A REFINED STRUCTURE... |
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[[Image:1h6i.gif|left|200px]]<br /> | [[Image:1h6i.gif|left|200px]]<br /><applet load="1h6i" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1h6i, resolution 3.54Å" /> | caption="1h6i, resolution 3.54Å" /> | ||
'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''<br /> | '''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''<br /> | ||
==Overview== | ==Overview== | ||
A refined structure of the human water channel aquaporin-1 is presented. | A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1H6I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1H6I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6I OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Engel, A.]] | [[Category: Engel, A.]] | ||
[[Category: Groot, B | [[Category: Groot, B L.De.]] | ||
[[Category: Grubmuller, H.]] | [[Category: Grubmuller, H.]] | ||
[[Category: electron diffraction]] | [[Category: electron diffraction]] | ||
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[[Category: water channel]] | [[Category: water channel]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:57:56 2008'' | ||
Revision as of 10:57, 21 February 2008
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A REFINED STRUCTURE OF HUMAN AQUAPORIN 1
Overview
A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.
Disease
Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]
About this Structure
1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455
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