1irx: Difference between revisions

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[[Image:1irx.gif|left|200px]]
{{Seed}}
[[Image:1irx.png|left|200px]]


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{{STRUCTURE_1irx|  PDB=1irx  |  SCENE=  }}  
{{STRUCTURE_1irx|  PDB=1irx  |  SCENE=  }}  


'''Crystal structure of class I lysyl-tRNA synthetase'''
===Crystal structure of class I lysyl-tRNA synthetase===




==Overview==
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Lysyl-tRNA can be synthesized by both a class I (LysRS-I) and a class II (LysRS-II) lysyl-tRNA synthetase. The crystal structure of LysRS-I from Pyrococcus horikoshii at 2.6 A resolution reveals extensive similarity with glutamyl-tRNA synthetase (GluRS). A comparison of the structures of LysRS-I and LysRS-II in complex with lysine shows that both enzymes use similar strategies for substrate recognition within unrelated active site topologies. A docking model based upon the GluRS-tRNA complex suggests how LysRS-I and LysRS-II can recognize the same molecular determinants in tRNALys, as shown by biochemical results, while approaching the acceptor helix of the tRNA from opposite sides.
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{{ABSTRACT_PUBMED_11887185}}


==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Zinc-binding structure]]
[[Category: Zinc-binding structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:20:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:53:43 2008''

Revision as of 10:53, 1 July 2008

File:1irx.png

Template:STRUCTURE 1irx

Crystal structure of class I lysyl-tRNA synthetase

Template:ABSTRACT PUBMED 11887185

About this Structure

1IRX is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Functional convergence of two lysyl-tRNA synthetases with unrelated topologies., Terada T, Nureki O, Ishitani R, Ambrogelly A, Ibba M, Soll D, Yokoyama S, Nat Struct Biol. 2002 Apr;9(4):257-62. PMID:11887185

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