1is4: Difference between revisions

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[[Image:1is4.~~jpg~~|left|200px]]

[[Image:1is4.png|left|200px]]

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~~'''~~LACTOSE-LIGANDED CONGERIN II~~'''~~

===LACTOSE-LIGANDED CONGERIN II===

~~==Overview==~~

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The ~~crystal structure of congerin II~~, ~~a galectin family lectin from conger eel~~, ~~was determined~~ at 1.~~45A resolution~~. ~~The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however~~, the ~~structure of congerin II described here resembles other prototype galectins~~. ~~A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2~~-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.

The line below this paragraph, {{ABSTRACT_PUBMED_12206768}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12206768 is the PubMed ID number.

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==About this Structure==

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[[Category: Beta sandwich]]

[[Category: Complex with lactose]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:20:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:54:27 2008''

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-[[Image:1is4.jpg|left|200px]]
+{{Seed}}
+[[Image:1is4.png|left|200px]]
 <!--
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 {{STRUCTURE_1is4|  PDB=1is4  |  SCENE=  }}
-'''LACTOSE-LIGANDED CONGERIN II'''
+===LACTOSE-LIGANDED CONGERIN II===
-==Overview==
+<!--
-The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.
+The line below this paragraph, {{ABSTRACT_PUBMED_12206768}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12206768 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12206768}}
 ==About this Structure==
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 [[Category: Beta sandwich]]
 [[Category: Complex with lactose]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:20:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 13:54:27 2008''