1is5: Difference between revisions

Line 1:

[[Image:1is5.~~jpg~~|left|200px]]

[[Image:1is5.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Ligand free Congerin II~~'''~~

===Ligand free Congerin II===

~~==Overview==~~

<!--

The ~~crystal structure of congerin II~~, ~~a galectin family lectin from conger eel~~, ~~was determined~~ at 1.~~45A resolution~~. ~~The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however~~, the ~~structure of congerin II described here resembles other prototype galectins~~. ~~A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2~~-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.

The line below this paragraph, {{ABSTRACT_PUBMED_12206768}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12206768 is the PubMed ID number.

-->

==About this Structure==

Line 31:

Line 35:

[[Category: Yamane, T.]]

[[Category: Beta sandwich]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:20:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:54:28 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1is5.jpg|left|200px]]
+{{Seed}}
+[[Image:1is5.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1is5|  PDB=1is5  |  SCENE=  }}
-'''Ligand free Congerin II'''
+===Ligand free Congerin II===
-==Overview==
+<!--
-The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.
+The line below this paragraph, {{ABSTRACT_PUBMED_12206768}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12206768 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12206768}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Yamane, T.]]
 [[Category: Beta sandwich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:20:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 13:54:28 2008''