1iu0: Difference between revisions

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[[Image:1iu0.jpg|left|200px]]
{{Seed}}
[[Image:1iu0.png|left|200px]]


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{{STRUCTURE_1iu0|  PDB=1iu0  |  SCENE=  }}  
{{STRUCTURE_1iu0|  PDB=1iu0  |  SCENE=  }}  


'''The first PDZ domain of PSD-95'''
===The first PDZ domain of PSD-95===




==Overview==
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PDZ domain proteins play critical roles in binding, clustering and subcellular targeting of membrane receptors and ion channels. PDZ domains in multi-PDZ proteins often are arranged in groups with highly conserved spacing and intervening sequences; however, the functional significance of such tandem arrangements of PDZs is unclear. We have solved the three-dimensional structure of the first two PDZ domains of postsynaptic density protein-95 (PSD-95 PDZ1 and PDZ2), which are closely linked to each other in the PSD-95 family of scaffold proteins. The two PDZs have limited freedom of rotation and their C-terminal peptide-binding grooves are aligned with each other with an orientation preference for binding to pairs of C termini extending in the same direction. Increasing the spacing between PDZ1 and PDZ2 resulted in decreased binding between PDZ12 and its dimeric targets. The same mutation impaired the functional ability of PSD-95 to cluster Kv1.4 potassium channels in heterologous cells. The data presented provide a molecular basis for preferential binding of PSD-95 to multimeric membrane proteins with appropriate C-terminal sequences.
The line below this paragraph, {{ABSTRACT_PUBMED_12614619}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12614619 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12614619}}


==About this Structure==
==About this Structure==
1IU0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU0 OCA].  
1IU0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU0 OCA].  


==Reference==
==Reference==
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[[Category: Post synaptic density]]
[[Category: Post synaptic density]]
[[Category: Psd-95]]
[[Category: Psd-95]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:24:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:59:47 2008''

Revision as of 10:59, 1 July 2008

File:1iu0.png

Template:STRUCTURE 1iu0

The first PDZ domain of PSD-95

Template:ABSTRACT PUBMED 12614619

About this Structure

1IU0 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95., Long JF, Tochio H, Wang P, Fan JS, Sala C, Niethammer M, Sheng M, Zhang M, J Mol Biol. 2003 Mar 14;327(1):203-14. PMID:12614619

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