1iu9: Difference between revisions

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[[Image:1iu9.jpg|left|200px]]
{{Seed}}
[[Image:1iu9.png|left|200px]]


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{{STRUCTURE_1iu9|  PDB=1iu9  |  SCENE=  }}  
{{STRUCTURE_1iu9|  PDB=1iu9  |  SCENE=  }}  


'''Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3'''
===Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3===




==Overview==
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The X-ray crystal structure has revealed two similar alpha/beta domains of aspartate racemase (AspR) from Pyrococcus horikoshii OT3, and identified a pseudo mirror-symmetric distribution of the residues around its active site [Liu et al. (2002) J. Mol. Biol. 319, 479-489]. Structural homology and functional similarity between the two domains suggested that this enzyme evolved from an ancestral domain by gene duplication and gene fusion. We have expressed solely the C-terminal domain of this AspR and determined its three-dimensional structure by X-ray crystallography. The high structural stability of this domain supports the existence of the ancestral domain. In comparison with other amino acid racemases (AARs), we suggest that gene duplication and gene fusion are conventional ways in the evolution of pyridoxal 5'-phosphate-independent AARs.
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==About this Structure==
==About this Structure==
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[[Category: C-terminal domain]]
[[Category: C-terminal domain]]
[[Category: Crystal structure]]
[[Category: Crystal structure]]
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