4h5j: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h5j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H5J FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h5j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H5J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.601&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5j OCA], [https://pdbe.org/4h5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h5j RCSB], [https://www.ebi.ac.uk/pdbsum/4h5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h5j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5j OCA], [https://pdbe.org/4h5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h5j RCSB], [https://www.ebi.ac.uk/pdbsum/4h5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h5j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SEC12_YEAST SEC12_YEAST] Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy.<ref>PMID:11694599</ref> <ref>PMID:12655150</ref> <ref>PMID:1327759</ref> <ref>PMID:16413259</ref> <ref>PMID:1649197</ref> <ref>PMID:1907973</ref> <ref>PMID:1907974</ref> <ref>PMID:1922074</ref> <ref>PMID:2512296</ref> <ref>PMID:3047151</ref> <ref>PMID:6996832</ref> <ref>PMID:7865879</ref> <ref>PMID:8106544</ref> <ref>PMID:8377826</ref> <ref>PMID:8583945</ref> <ref>PMID:9023343</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Latest revision as of 02:58, 21 November 2024

Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P64 form)

4h5j, resolution 2.60Å

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