1ixs: Difference between revisions

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[[Image:1ixs.gif|left|200px]]
{{Seed}}
[[Image:1ixs.png|left|200px]]


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{{STRUCTURE_1ixs|  PDB=1ixs  |  SCENE=  }}  
{{STRUCTURE_1ixs|  PDB=1ixs  |  SCENE=  }}  


'''Structure of RuvB complexed with RuvA domain III'''
===Structure of RuvB complexed with RuvA domain III===




==Overview==
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We present the X-ray structure of the RuvA-RuvB complex, which plays a crucial role in ATP-dependent branch migration. Two RuvA tetramers form the symmetric and closed octameric shell, where four RuvA domain IIIs spring out in the two opposite directions to be individually caught by a single RuvB. The binding of domain III deforms the protruding beta hairpin in the N-terminal domain of RuvB and thereby appears to induce a functional and less symmetric RuvB hexameric ring. The model of the RuvA-RuvB junction DNA ternary complex, constructed by fitting the X-ray structure into the averaged electron microscopic images of the RuvA-RuvB junction, appears to be more compatible with the branch migration mode of a fixed RuvA-RuvB interaction than with a rotational interaction mode.
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{{ABSTRACT_PUBMED_12408833}}


==About this Structure==
==About this Structure==
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[[Category: Complex with nucleotide]]
[[Category: Complex with nucleotide]]
[[Category: Heterodimeric protein complex]]
[[Category: Heterodimeric protein complex]]
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