1ixz: Difference between revisions

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[[Image:1ixz.~~gif~~|left|200px]]

[[Image:1ixz.png|left|200px]]

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~~'''~~Crystal structure of the FtsH ATPase domain from Thermus thermophilus~~'''~~

===Crystal structure of the FtsH ATPase domain from Thermus thermophilus===

~~==Overview==~~

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~~FtsH is a cytoplasmic membrane~~-~~integrated, ATP~~-~~dependent metalloprotease~~, which processively degrades both cytoplasmic and membrane proteins in concert with unfolding. The FtsH protein is divided into the N-terminal transmembrane region and the larger C-terminal cytoplasmic region, ~~which consists of an ATPase domain and a protease domain. We have determined the crystal structures of the Thermus thermophilus FtsH ATPase domain in~~ the ~~nucleotide-free and AMP-PNP- and ADP-bound states, in addition~~ to the ~~domain with the extra preceding segment~~. ~~Combined with the mapping of the putative substrate binding region~~, these structures suggest that FtsH internally forms a hexameric ring structure, in which ATP binding could cause a conformational change to facilitate transport of substrates into the protease domain through the ~~central pore~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12377127}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12377127 is the PubMed ID number.

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==About this Structure==

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[[Category: Yoshida, M.]]

[[Category: Aaa domain fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:33:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:11:54 2008''

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-[[Image:1ixz.gif|left|200px]]
+{{Seed}}
+[[Image:1ixz.png|left|200px]]
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 {{STRUCTURE_1ixz|  PDB=1ixz  |  SCENE=  }}
-'''Crystal structure of the FtsH ATPase domain from Thermus thermophilus'''
+===Crystal structure of the FtsH ATPase domain from Thermus thermophilus===
-==Overview==
+<!--
-FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in concert with unfolding. The FtsH protein is divided into the N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. We have determined the crystal structures of the Thermus thermophilus FtsH ATPase domain in the nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the domain with the extra preceding segment. Combined with the mapping of the putative substrate binding region, these structures suggest that FtsH internally forms a hexameric ring structure, in which ATP binding could cause a conformational change to facilitate transport of substrates into the protease domain through the central pore.
+The line below this paragraph, {{ABSTRACT_PUBMED_12377127}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12377127 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12377127}}
 ==About this Structure==
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 [[Category: Yoshida, M.]]
 [[Category: Aaa domain fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:33:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 14:11:54 2008''