4hvz: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_S19 Brucella abortus S19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HVZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_S19 Brucella abortus S19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HVZ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvz OCA], [https://pdbe.org/4hvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hvz RCSB], [https://www.ebi.ac.uk/pdbsum/4hvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hvz ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvz OCA], [https://pdbe.org/4hvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hvz RCSB], [https://www.ebi.ac.uk/pdbsum/4hvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hvz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/BP26_BRUA1 BP26_BRUA1]  
[https://www.uniprot.org/uniprot/BP26_BRUA1 BP26_BRUA1]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
An outer membrane protein BP26/OMP28 of Brucella, BP26, is identified as a major immunodominant antigen and widely used as a diagnostic marker and for vaccination against Brucellosis. BP26 belongs to the family of proteins that contains a SIMPL (signaling molecule that associates with the mouse pelle-like kinase) domain, whose structure and function have been unknown. Here, we present the crystal structure of BP26 revealing that 16 BP26 molecules form a novel channel-like assembly as also shown by electron microscopy analysis. Eight BP26 molecules forming a ring structure contain a hole at the center of the octamer, and another octamer interacts with each other to form a channel having a large internal cavity. BP26 is found to be structurally similar to a bacteriophage protein involved in infection, implicating that BP26 might function during Brucella infection. In addition, the BP26 structure suggests that the protein functions as a multimeric channel-like form and provides a canonical model for the SIMPL domains.
Brucella Immunogenic BP26 Forms a Channel-like Structure.,Kim D, Park J, Kim SJ, Soh YM, Kim HM, Oh BH, Song JJ J Mol Biol. 2013 Jan 23. pii: S0022-2836(13)00031-4. doi:, 10.1016/j.jmb.2013.01.015. PMID:23353825<ref>PMID:23353825</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4hvz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
</StructureSection>
Retrieved from "https://proteopedia.org/4hvz"