1iyv: Difference between revisions

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[[Image:1iyv.gif|left|200px]]
{{Seed}}
[[Image:1iyv.png|left|200px]]


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{{STRUCTURE_1iyv|  PDB=1iyv  |  SCENE=  }}  
{{STRUCTURE_1iyv|  PDB=1iyv  |  SCENE=  }}  


'''LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, 29 STRUCTURES'''
===LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, 29 STRUCTURES===




==Overview==
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The three-dimensional structure of the N-terminal lipoyl domain of the acetyltransferase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii has been determined using heteronuclear multidimensional NMR spectroscopy and dynamical simulated annealing. The structure is compared with the solution structure of the lipoyl domain of the A. vinelandii 2-oxoglutarate dehydrogenase complex. The overall fold of the two structures, described as a beta-barrel-sandwich hybrid, is very similar. This agrees well with the high similarity of NMR-derived parameters, e.g. chemical shifts, between the two lipoyl domains. The main structural differences between the two lipoyl domains occur in a solvent-exposed loop close in space to the lipoylation site. Despite their high structural similarity, these lipoyl domains show a high preference for being reductively acylated by their parent 2-oxo acid dehydrogenase. Potential residues of the lipoyl domain involved in this process of molecular recognition are discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_9119000}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9119000 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9119000}}


==About this Structure==
==About this Structure==
1IYV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYV OCA].  
1IYV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYV OCA].  


==Reference==
==Reference==
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[[Category: Lipoyl]]
[[Category: Lipoyl]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:36:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:14:33 2008''

Revision as of 11:14, 1 July 2008

File:1iyv.png

Template:STRUCTURE 1iyv

LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, 29 STRUCTURES

Template:ABSTRACT PUBMED 9119000

About this Structure

1IYV is a Single protein structure of sequence from Azotobacter vinelandii. Full experimental information is available from OCA.

Reference

Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter vinelandii., Berg A, Vervoort J, de Kok A, Eur J Biochem. 1997 Mar 1;244(2):352-60. PMID:9119000

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