Sandbox Q123

spinqualitylabelsall models Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code 3m7p) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural insights Fn is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of repeating units: FnI, FnII and FnIII. Type I and type II repeats are disulfide-bonded loops, containing about 45 and 60 amino-acids each, while type III repeats are about 90 amino-acids long without S-S bonds. Each module contains several numbered protein binding domains, i.e., FnI6-FnII1-2-FnI7-9 is the gelatin binding domain (GBD). Function Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It plays an important role in cell adhesion, migration and differentiation. In addition, Fn is also important for the adherence of pathogens to host tissues and the linking between proteins and cells. Relevance Fn is associated with inflammation area and the process of wound healing. Fn is a potential marker for radiation resistance. Disease Overexpression of Fn1 is associated with lung cancer. 3D Structures of Fibronectin Fibronectin 3D structures