Sandbox Reserved 1741: Difference between revisions
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== Relevance == | == Relevance == | ||
The finding of HIV-1 RT was monumental for offering treatment to individuals living with HIV-1. After its discovery, the development of nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), which are responsible for inhibition of different mechanisms of reverse transcription (6). | |||
== Structural highlights == | == Structural highlights == | ||
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Note: We will adjust the references to go in sequential order once we are finished with references, as we plan to add more information with more references looking forward. | Note: We will adjust the references to go in sequential order once we are finished with references, as we plan to add more information with more references looking forward. | ||
(1)Kati, W.M.; Johnson, K.A.; Jerver, L.F.; Anderson, K.F. Mechanism and Fidelity of HIV Reverse | (1) Kati, W.M.; Johnson, K.A.; Jerver, L.F.; Anderson, K.F. Mechanism and Fidelity of HIV Reverse | ||
Transcriptase. ''J. Biol. Chem.'' '''1992''', ''267''(36), 25988-25997 | Transcriptase. ''J. Biol. Chem.'' '''1992''', ''267''(36), 25988-25997 | ||
(2)Abbondanzieri, E. A.; Bokinsky, G.; Rausch, J. W.; Zhang, J. X.; Le Grice, S. F.; | (2) Abbondanzieri, E. A.; Bokinsky, G.; Rausch, J. W.; Zhang, J. X.; Le Grice, S. F.; | ||
Zhuang, X. Dynamic Binding Orientations Direct Activity of HIV Reverse Transcriptase. | Zhuang, X. Dynamic Binding Orientations Direct Activity of HIV Reverse Transcriptase. | ||
''Nat.'' '''2008''', ''453''(7192), 184–189. | ''Nat.'' '''2008''', ''453''(7192), 184–189. | ||
(3)Esposito, F.; Corona, A.; Tramontano, E. HIV-1 Reverse Transcriptase Still Remains a New Drug | (3) Esposito, F.; Corona, A.; Tramontano, E. HIV-1 Reverse Transcriptase Still Remains a New Drug | ||
Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms | Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms | ||
of Actions. ''Mol. Biol. Int.'' '''2012''', ''2012'', 1–23. | of Actions. ''Mol. Biol. Int.'' '''2012''', ''2012'', 1–23. | ||
(4)Hu, W. S.; Hughes, S. HIV-1 Reverse Transcription. ''Cold Spring Harb. Prospect. Med.'' '''2012''' ''2''(10) doi: 10.1101/cshperspect.a006882 | (4) Hu, W. S.; Hughes, S. HIV-1 Reverse Transcription. ''Cold Spring Harb. Prospect. Med.'' '''2012''' ''2''(10) doi: 10.1101/cshperspect.a006882 | ||
(5) Morier, D. Reverse transcriptase. https://www.britannica.com/science/reverse-transcriptase (accessed Nov 14, 2022). | (5) Morier, D. Reverse transcriptase. https://www.britannica.com/science/reverse-transcriptase (accessed Nov 14, 2022). | ||
(6) Singh, A. K.; Das, K. Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies. Viruses 2022, 14 (5), 1027. | |||
