Sandbox Reserved 1741: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
HIV reverse transcriptase is a heterodimer with chains of 66 kDA and 51 kDA. P66 chain is proteolytically processed by HIV protease to form the smaller unit of the heterodimer. HIV-1 reverse transcriptase produces a homodimer p66/p66 and a heterodimer p66/p51 when expressed in bacteria. Ribonucleases H (RNase H) are enzymes that cleavage the RNA of DNA/RNA hybrid. In reverse transcriptase the hydrolysis of an RNA strand in a DNA/RNA hybrid generates 5' phosphate and 3’ hydroxyl ends. | |||
== References == | == References == | ||
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(6) Singh, A. K.; Das, K. Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies. Viruses 2022, 14 (5), 1027. | (6) Singh, A. K.; Das, K. Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies. Viruses 2022, 14 (5), 1027. | ||
(7) Jacobo-Molina, A.; Arnold, E. Perspectives in Biochemistry: HIV Reverse Transcriptase Structure-Function Relationships. Biochem. 1991, 30 (26), 6351-6361. | |||
