1izz: Difference between revisions

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[[Image:1izz.jpg|left|200px]]
{{Seed}}
[[Image:1izz.png|left|200px]]


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{{STRUCTURE_1izz|  PDB=1izz  |  SCENE=  }}  
{{STRUCTURE_1izz|  PDB=1izz  |  SCENE=  }}  


'''Crystal structure of Hsp31'''
===Crystal structure of Hsp31===




==Overview==
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Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_12939276}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12939276 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12939276}}


==About this Structure==
==About this Structure==
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[[Category: Lee, S J.]]
[[Category: Lee, S J.]]
[[Category: Alpha-beta sandwitch]]
[[Category: Alpha-beta sandwitch]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:38:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:17:19 2008''
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