8d2s: Difference between revisions
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==Zebrafish MFSD2A isoform B in inward open ligand bound conformation== | |||
<StructureSection load='8d2s' size='340' side='right'caption='[[8d2s]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8d2s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D2S FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZGS:[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl]+(9~{Z},12~{Z},15~{Z})-octadeca-9,12,15-trienoate'>ZGS</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d2s OCA], [https://pdbe.org/8d2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d2s RCSB], [https://www.ebi.ac.uk/pdbsum/8d2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d2s ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NLS1B_DANRE NLS1B_DANRE] Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.[UniProtKB:Q9DA75] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Danio rerio]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Gallentino MJ]] | |||
[[Category: Gonen T]] | |||
[[Category: Lai LTF]] | |||
[[Category: Lei HT]] | |||
[[Category: Matthies D]] | |||
[[Category: Mu X]] | |||
[[Category: Nguyen C]] | |||
Revision as of 06:53, 10 May 2023
Zebrafish MFSD2A isoform B in inward open ligand bound conformation
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