8esi: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8esi is ~~ON HOLD until Paper Publication~~

==Bile Salt Hydrolase from B. longum with covalent inhibitor bound==

~~Authors~~: ~~Walker~~, M.E., ~~Lim~~, L., ~~Redinbo~~, M.R.

== Structural highlights ==

<table><tr><td colspan='2'>[[8esi]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESI OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8ESI FirstGlance].

~~Description~~: Bile ~~Salt Hydrolase from B~~. longum ~~with covalent inhibitor bound~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WSR:(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl+hydrogen+sulfate+(non-preferred+name)'>WSR</scene></td></tr>

[[Category: Lim, L]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8esi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8esi OCA], [https://pdbe.org/8esi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8esi RCSB], [https://www.ebi.ac.uk/pdbsum/8esi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8esi ProSAT]</td></tr>

[[Category: ~~Walker, M.E~~]]

</table>

[[Category: ~~Redinbo, M.R~~]]

== Function ==

[https://www.uniprot.org/uniprot/CBH_BIFLN CBH_BIFLN] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539).<ref>PMID:10831430</ref> <ref>PMID:16905539</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bifidobacterium longum]]

[[Category: Large Structures]]

[[Category: Lim L]]

[[Category: Redinbo MR]]

[[Category: Walker ME]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8esi is ON HOLD  until Paper Publication
+==Bile Salt Hydrolase from B. longum with covalent inhibitor bound==
+<StructureSection load='8esi' size='340' side='right'caption='[[8esi]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-Authors: Walker, M.E., Lim, L., Redinbo, M.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8esi]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESI FirstGlance]. <br>
-Description: Bile Salt Hydrolase from B. longum with covalent inhibitor bound
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WSR:(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl+hydrogen+sulfate+(non-preferred+name)'>WSR</scene></td></tr>
-[[Category: Lim, L]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8esi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8esi OCA], [https://pdbe.org/8esi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8esi RCSB], [https://www.ebi.ac.uk/pdbsum/8esi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8esi ProSAT]</span></td></tr>
-[[Category: Walker, M.E]]
+</table>
-[[Category: Redinbo, M.R]]
+== Function ==
+[https://www.uniprot.org/uniprot/CBH_BIFLN CBH_BIFLN] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539).<ref>PMID:10831430</ref> <ref>PMID:16905539</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bifidobacterium longum]]
+[[Category: Large Structures]]
+[[Category: Lim L]]
+[[Category: Redinbo MR]]
+[[Category: Walker ME]]