Sandbox Reserved 1732: Difference between revisions

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There are two main conformations of full-length insulin receptors, U-shaped and T-shaped. The U-shaped conformation exists when there is an absence of insulin on the protein, whereas the T-shaped and II-shaped conformations exist in the presence of insulin. The U-shaped conformation is also known as the auto-inhibited state. In this state, the L1 domain contacts the L1’ and L2’ domains of the partnering protein. When insulin binds to the receptor protein, it causes a conformational change from the U-shape to the T-shape conformation.  
There are two main conformations of full-length insulin receptors, U-shaped and T-shaped. The U-shaped conformation exists when there is an absence of insulin on the protein, whereas the T-shaped and II-shaped conformations exist in the presence of insulin. The U-shaped conformation is also known as the auto-inhibited state. In this state, the L1 domain contacts the L1’ and L2’ domains of the partnering protein. When insulin binds to the receptor protein, it causes a conformational change from the U-shape to the T-shape conformation.  


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
== References ==
== References ==


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