Androgen receptor: Difference between revisions
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=Pharmacology <span class="fas fa-capsules"></span>= | =Pharmacology <span class="fas fa-capsules"></span>= | ||
== | ==Steroidal Drugs== | ||
===Natural ligand: Testosterone=== | ===Natural ligand: Testosterone=== | ||
Aging and other factors are associated with a reduction of testosterone levels which could lead to late onset hypogonadism <ref name="hypogonadism">PMID: 32737921</ref>. The decrease of the T levels and therefore its active metabolite levels (DHT) are related with several symptoms such as low libido, erectile dysfunction, skeletal muscular loss <ref name="NR" /><ref name="hypogonadism" />, increased cardiovascular risk <ref name="hypogonadism" />, etc. To treat those symptoms is used Testosterone Restitution Therapy (TRT) which has been associated with the improvement in sexual function and the increase in muscle mass and bone mineral density <ref name="Testosterone">PMID: 34888506</ref>. | Aging and other factors are associated with a reduction of testosterone levels which could lead to late onset hypogonadism <ref name="hypogonadism">PMID: 32737921</ref>. The decrease of the T levels and therefore its active metabolite levels (DHT) are related with several symptoms such as low libido, erectile dysfunction, skeletal muscular loss <ref name="NR" /><ref name="hypogonadism" />, increased cardiovascular risk <ref name="hypogonadism" />, etc. To treat those symptoms is used Testosterone Restitution Therapy (TRT) which has been associated with the improvement in sexual function and the increase in muscle mass and bone mineral density <ref name="Testosterone">PMID: 34888506</ref>. | ||
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Because of the doping scandals in the athlete community, the World Anti-Doping Agency (WADA) has prohibited them <ref name="Steroids" />. This creates the need to discover androgens that have beneficial anabolic activity with reduced androgenic activity. | Because of the doping scandals in the athlete community, the World Anti-Doping Agency (WADA) has prohibited them <ref name="Steroids" />. This creates the need to discover androgens that have beneficial anabolic activity with reduced androgenic activity. | ||
==Non- | ==Non-Steroidal Drugs== | ||
===Selective Androgen Receptor Modulators (SARMs)=== | ===Selective Androgen Receptor Modulators (SARMs)=== | ||
Steroid androgens can be associated with a high rate of adverse effects, which limits their widespread clinical use. To overcome these side effects, SARMs were developed. | Steroid androgens can be associated with a high rate of adverse effects, which limits their widespread clinical use. To overcome these side effects, SARMs were developed. | ||
