Androgen receptor: Difference between revisions

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The androgen receptor (AR) belongs to the steroid hormone group nuclear receptor family with the estrogen, progesterone, glucocorticoid and mineralcorticoid receptor.

The androgen receptor (AR) belongs to the steroid hormone group nuclear receptor family together with the estrogen, progesterone, glucocorticoid and mineralcorticoid receptor.

AR ~~mediate~~ the actions of testosterone (T) and a more biologically active form, 5α-dihydrotestosterone (DHT), which are the male sex hormones required for development of the male reproductive system and secondary sexual characteristics. This receptor, located on the X chromosome, has significant biological actions in many systems, because it is expressed in a diverse range of tissues <ref name="Bench to Bedside">PMID: 27057074</ref>. ~~There are other~~ androgens that bind with much less potency than T and DHT ~~such as~~ androstenedione, androstenediol, and dehydroepiandrosterone (DHEA) <ref>PMID: 36376977</ref>.

AR mediates the actions of testosterone (T) and a more biologically active form, 5α-dihydrotestosterone (DHT), which are the male sex hormones required for development of the male reproductive system and secondary sexual characteristics. This receptor, located on the X chromosome, has significant biological actions in many systems, because it is expressed in a diverse range of tissues <ref name="Bench to Bedside">PMID: 27057074</ref>. Other androgens that bind with much less potency than T and DHT are androstenedione, androstenediol, and dehydroepiandrosterone (DHEA) <ref>PMID: 36376977</ref>.

__TOC__

=Structure=

~~Like~~ members of the nuclear receptor family, the AR consists of three main functional domains which aid in controlling and regulating transcriptional activity.

Similar to other members of the nuclear receptor family, the AR consists of three main functional domains which aid in controlling and regulating transcriptional activity.

==Domains==

Androgen receptor: Difference between revisions

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 <StructureSection load='3b5r' size='340' side='right' caption='Human androgen receptor ligand-binding domain complex with modulator (PDB entry [[3b5r]])' scene='54/543362/Ar/1'>
-The androgen receptor (AR) belongs to the steroid hormone group nuclear receptor family with the estrogen, progesterone, glucocorticoid and mineralcorticoid receptor.
+The androgen receptor (AR) belongs to the steroid hormone group nuclear receptor family together with the estrogen, progesterone, glucocorticoid and mineralcorticoid receptor.
-AR mediate the actions of testosterone (T) and a more biologically active form, 5α-dihydrotestosterone (DHT), which are the male sex hormones required for development of the male reproductive system and secondary sexual characteristics. This receptor, located on the X chromosome, has significant biological actions in many systems, because it is expressed in a diverse range of tissues <ref name="Bench to Bedside">PMID: 27057074</ref>. There are other androgens that bind with much less potency than T and DHT such as androstenedione, androstenediol, and dehydroepiandrosterone (DHEA) <ref>PMID: 36376977</ref>.
+AR mediates the actions of testosterone (T) and a more biologically active form, 5α-dihydrotestosterone (DHT), which are the male sex hormones required for development of the male reproductive system and secondary sexual characteristics. This receptor, located on the X chromosome, has significant biological actions in many systems, because it is expressed in a diverse range of tissues <ref name="Bench to Bedside">PMID: 27057074</ref>. Other androgens that bind with much less potency than T and DHT are androstenedione, androstenediol, and dehydroepiandrosterone (DHEA) <ref>PMID: 36376977</ref>.
 __TOC__
 =Structure=
-Like members of the nuclear receptor family, the AR consists of three main functional domains which aid in controlling and regulating transcriptional activity.
+Similar to other members of the nuclear receptor family, the AR consists of three main functional domains which aid in controlling and regulating transcriptional activity.
 ==Domains==