8f7x: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
m Protected "8f7x" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 8f7x is ON HOLD
==Gi bound nociceptin receptor in complex with nociceptin peptide==
 
<StructureSection load='8f7x' size='340' side='right'caption='[[8f7x]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8f7x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F7X FirstGlance]. <br>
Description: Gi bound nociceptin receptor in complex with nociceptin peptide
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f7x OCA], [https://pdbe.org/8f7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f7x RCSB], [https://www.ebi.ac.uk/pdbsum/8f7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f7x ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Zhou, X.E]]
== Function ==
[[Category: Xu, H.E]]
[https://www.uniprot.org/uniprot/OPRX_HUMAN OPRX_HUMAN] G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.<ref>PMID:11238602</ref> <ref>PMID:12568343</ref> <ref>PMID:22596163</ref> <ref>PMID:23086955</ref> <ref>PMID:8137918</ref>
[[Category: Jain, M.K]]
== References ==
[[Category: Melcher, K]]
<references/>
[[Category: Liu, W]]
__TOC__
[[Category: Diberto, J.F]]
</StructureSection>
[[Category: Jiang, Y]]
[[Category: Bos taurus]]
[[Category: Wang, Y]]
[[Category: Homo sapiens]]
[[Category: Zhuang, Y]]
[[Category: Large Structures]]
[[Category: Roth, B.L]]
[[Category: Rattus norvegicus]]
[[Category: Yuan, Q]]
[[Category: Synthetic construct]]
[[Category: Schmitz, G.P]]
[[Category: DiBerto JF]]
[[Category: Jain MK]]
[[Category: Jiang Y]]
[[Category: Liu W]]
[[Category: Melcher K]]
[[Category: Roth BL]]
[[Category: Schmitz GP]]
[[Category: Wang Y]]
[[Category: Xu HE]]
[[Category: Yuan Q]]
[[Category: Zhou XE]]
[[Category: Zhuang Y]]
Retrieved from "https://proteopedia.org/8f7x"