Gluconeogenesis: Difference between revisions
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'''4)''' <scene name='43/430893/Cv/3'>Oxaloacetate</scene> is decarboxylated and then phosphorylated to form <scene name='39/392339/Cv1/8'>phosphoenolpyruvate</scene> using the enzyme [[PEPCK]]. A molecule of GTP is hydrolyzed to GDP during this reaction. | '''4)''' <scene name='43/430893/Cv/3'>Oxaloacetate</scene> is decarboxylated and then phosphorylated to form <scene name='39/392339/Cv1/8'>phosphoenolpyruvate</scene> using the enzyme [[PEPCK]]. A molecule of GTP is hydrolyzed to GDP during this reaction. | ||
The next steps in the reaction are the same as reversed glycolysis. However, [[fructose 1,6-bisphosphatase]] converts fructose 1,6-bisphosphate to fructose 6-phosphate, using one water molecule and releasing one phosphate (in glycolysis, phosphofructokinase 1 converts F6P and ATP to F1,6BP and ADP). This is also the rate-limiting step of gluconeogenesis. | The next steps in the reaction are the same as reversed glycolysis. However, [[fructose 1,6-bisphosphatase]] converts <scene name='39/392339/Cv1/2'>fructose 1,6-bisphosphate</scene> to <scene name='92/925544/Cv/5'>fructose 6-phosphate</scene>, using one water molecule and releasing one phosphate (in glycolysis, phosphofructokinase 1 converts F6P and ATP to F1,6BP and ADP). This is also the rate-limiting step of gluconeogenesis. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
