1hrp: Difference between revisions

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[[Image:1hrp.gif|left|200px]]<br />

[[Image:1hrp.gif|left|200px]]<br /><applet load="1hrp" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1hrp" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1hrp, resolution 3.0Å" />

'''CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN'''<br />

==Overview==

The three-dimensional structure of human chorionic gonadotropin shows that, each of its two different subunits has a similar topology, with three, disulphide bonds forming a cystine knot. This same folding motif is found, in some protein growth factors. The heterodimer is stabilized by a segment, of the beta-subunit which wraps around the alpha-subunit and is covalently, linked like a seat belt by the disulphide Cys 26-Cys 110. This, extraordinary feature appears to be essential not only for the association, of these heterodimers but also for receptor binding by the glycoprotein, hormones.

The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.

==About this Structure==

1HRP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].

1HRP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].

==Reference==

Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8202136 8202136]

[[Category: Protein complex]]

[[Category: Harris, D.C.]]

[[Category: Harris, D C.]]

[[Category: Isaacs, N.W.]]

[[Category: Isaacs, N W.]]

[[Category: Lapthorn, A.J.]]

[[Category: Lapthorn, A J.]]

[[Category: NAG]]

[[Category: hormone]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:21:~~37 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:18 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1hrp.gif|left|200px]]<br />
+[[Image:1hrp.gif|left|200px]]<br /><applet load="1hrp" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1hrp" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1hrp, resolution 3.0&Aring;" />
 '''CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN'''<br />
 ==Overview==
-The three-dimensional structure of human chorionic gonadotropin shows that, each of its two different subunits has a similar topology, with three, disulphide bonds forming a cystine knot. This same folding motif is found, in some protein growth factors. The heterodimer is stabilized by a segment, of the beta-subunit which wraps around the alpha-subunit and is covalently, linked like a seat belt by the disulphide Cys 26-Cys 110. This, extraordinary feature appears to be essential not only for the association, of these heterodimers but also for receptor binding by the glycoprotein, hormones.
+The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.
 ==About this Structure==
-HRP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].
+HRP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].
 ==Reference==
 Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8202136 8202136]
 [[Category: Protein complex]]
-[[Category: Harris, D.C.]]
+[[Category: Harris, D C.]]
-[[Category: Isaacs, N.W.]]
+[[Category: Isaacs, N W.]]
-[[Category: Lapthorn, A.J.]]
+[[Category: Lapthorn, A J.]]
 [[Category: NAG]]
 [[Category: hormone]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:21:37 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:18 2008''