1j9l: Difference between revisions

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[[Image:1j9l.~~gif~~|left|200px]]

[[Image:1j9l.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH VANADATE~~'''~~

===CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH VANADATE===

~~==Overview==~~

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~~Homologs of~~ the ~~Escherichia coli surE gene are present in many eubacteria and archaea. Despite~~ the ~~evolutionary conservation, little information is available~~ on ~~the structure and function of their gene products~~. ~~We have determined the crystal structure of the SurE protein from Thermotoga maritima~~. ~~The structure reveals the dimeric arrangement of~~ the ~~subunits and an active site around a bound metal ion~~. ~~We also demonstrate that the SurE protein exhibits a divalent metal ion~~-~~dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate~~- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.

The line below this paragraph, {{ABSTRACT_PUBMED_11524683}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11524683 is the PubMed ID number.

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==About this Structure==

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[[Category: Sure protein]]

[[Category: Vanadate complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:57:06 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:43:39 2008''

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-[[Image:1j9l.gif|left|200px]]
+{{Seed}}
+[[Image:1j9l.png|left|200px]]
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 {{STRUCTURE_1j9l|  PDB=1j9l  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH VANADATE'''
+===CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH VANADATE===
-==Overview==
+<!--
-Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.
+The line below this paragraph, {{ABSTRACT_PUBMED_11524683}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11524683 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11524683}}
 ==About this Structure==
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 [[Category: Sure protein]]
 [[Category: Vanadate complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:57:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 14:43:39 2008''