Sandbox Reserved 1760: Difference between revisions
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== Function of your protein == | == Function of your protein == | ||
The function of hOAT is to catalyze the transfer of the amino group from L-ornithine to an α-ketoglutarate. | The function of hOAT is to catalyze the transfer of the amino group from L-ornithine to an α-ketoglutarate. | ||
== Biological relevance and broader implications == | == Biological relevance and broader implications == | ||
hOAT is found in most tissues in the body but predominates in the liver and kidney. There is a need to study the enzyme hOAT because the overexpression of this protein aids the proliferation of cancer cells, specifically Hepatocellular carcinoma (HCC), a common form of liver cancer. hOAT has been a target for mechanism-based inactivators (MBIs) in ongoing drug design efforts. HCC is normally diagnosed at advanced stages where the tumors tend to be resistant to radiotherapy and chemotherapy, making this type of cancer difficult to treat. | hOAT is found in most tissues in the body but predominates in the liver and kidney. There is a need to study the enzyme hOAT because the overexpression of this protein aids the proliferation of cancer cells, specifically Hepatocellular carcinoma (HCC), a common form of liver cancer. hOAT has been a target for mechanism-based inactivators (MBIs) in ongoing drug design efforts. HCC is normally diagnosed at advanced stages where the tumors tend to be resistant to radiotherapy and chemotherapy, making this type of cancer difficult to treat. | ||
