Sandbox Reserved 1758: Difference between revisions
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''Picrophilus Torridus'' undergoes Thermoplasma-type MVA (mevalonate) pathway, the enzyme produces ADP in this pathway. This is relevant because the journal is analyzing a distinction between a novel variant of the eukaryotic MVA pathway. When the enzyme binds to a fatty-acid-like structure there is no ATP required for the reaction. There is an evolutionary route from ATP dependent to ATP-independent with the loss of kinase ability. | ''Picrophilus Torridus'' undergoes Thermoplasma-type MVA (mevalonate) pathway, the enzyme produces ADP in this pathway. This is relevant because the journal is analyzing a distinction between a novel variant of the eukaryotic MVA pathway. When the enzyme binds to a fatty-acid-like structure there is no ATP required for the reaction. There is an evolutionary route from ATP dependent to ATP-independent with the loss of kinase ability. | ||
== Important amino acids== | == Important amino acids== | ||
The <scene name='93/934002/Asp_281_asp_309/1'>catalytic dyad</scene> is composed of Asp 281 and Asp 309<ref>PMID:35690147</ref>.<scene name='93/934002/Ligand/2'>ligand</scene> | |||
The <scene name='93/934002/Asp_281_asp_309/1'>catalytic dyad</scene> is composed of Asp 281 and Asp 309<ref>PMID:35690147</ref>.The internal surface of the cavity contains hydrophobic amino acid residues. The opening of the cavity holds charged or polar residues including Lys 94, Tyr 99, Arg 128, and Glu 138. This suggests an amphipathic <scene name='93/934002/Ligand/2'>ligand</scene>, such as Oleic Acid, a fatty acid. Oleic Acid is an amphipathic fatty acid. One end has a carboxylic acid which has a hydrogen bond with Arg 148 and a water molecule. The Oleic Acid chain of carbons is surrounded by non-polar amino acids such as valine. | |||
== Structural highlights == | == Structural highlights == | ||
Secondary Structure | Secondary Structure | ||
