7tyj: Difference between revisions
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The | ==Cryo-EM Structure of insulin receptor-related receptor (IRR) in apo-state captured at pH 7. The 3D refinement was focused on one of two halves with C1 symmetry applied== | ||
<StructureSection load='7tyj' size='340' side='right'caption='[[7tyj]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7tyj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TYJ FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tyj OCA], [https://pdbe.org/7tyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tyj RCSB], [https://www.ebi.ac.uk/pdbsum/7tyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tyj ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/INSRR_HUMAN INSRR_HUMAN] Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.<ref>PMID:21641549</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bai XC]] | |||
[[Category: Choi E]] | |||
[[Category: Hall C]] | |||
[[Category: Li J]] | |||
[[Category: Wang LW]] | |||
