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| {{STRUCTURE_1jbe| PDB=1jbe | SCENE= }} | | {{STRUCTURE_1jbe| PDB=1jbe | SCENE= }} |
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| '''1.08 A Structure of apo-Chey reveals meta-active conformation'''
| | ===1.08 A Structure of apo-Chey reveals meta-active conformation=== |
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| ==Overview==
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| CheY is the best characterized member of the response regulator superfamily, and as such it has become the principal model for understanding the initial molecular mechanisms of signaling in two-component systems. Normal signaling by response regulators requires phosphorylation, in combination with an activation mechanism whose conformational effects are not completely understood. CheY activation involves three events, phosphorylation, a conformational change in the beta(4)--alpha(4) loop, and a rotational restriction of the side chain of tyrosine 106. An outstanding question concerns the nature of an active conformation in the apoCheY population. The details of this 1.08-A resolution crystal structure of wild-type apoCheY shows the beta(4)--alpha(4) loop in two distinctly different conformations that sterically correlate with the two rotameric positions of the tyrosine 106 side chain. One of these conformational states of CheY is the inactive form, and we propose that the other is a meta-active form, responsible for the active properties seen in apoCheY.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11410584}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11410584 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11410584}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Chemotaxis]] | | [[Category: Chemotaxis]] |
| [[Category: Chey]] | | [[Category: Chey]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:00:49 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 19:58:10 2008'' |
