8hkw: Difference between revisions
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==Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal== | |||
<StructureSection load='8hkw' size='340' side='right'caption='[[8hkw]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8hkw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKW FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hkw OCA], [https://pdbe.org/8hkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hkw RCSB], [https://www.ebi.ac.uk/pdbsum/8hkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hkw ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Matsuura | == Disease == | ||
[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Matsuura Y]] | |||
Revision as of 09:31, 21 December 2022
Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
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