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==Capsid structure of Staphylococcus phage Andhra==
==Capsid structure of Staphylococcus phage Andhra==
<StructureSection load='8egt' size='340' side='right'caption='[[8egt]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<SX load='8egt' size='340' side='right' viewer='molstar' caption='[[8egt]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8egt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rakietenvirinae Rakietenvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EGT FirstGlance]. <br>
<table><tr><td colspan='2'>[[8egt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rakietenvirinae Rakietenvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EGT FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8egt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8egt OCA], [https://pdbe.org/8egt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8egt RCSB], [https://www.ebi.ac.uk/pdbsum/8egt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8egt ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8egt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8egt OCA], [https://pdbe.org/8egt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8egt RCSB], [https://www.ebi.ac.uk/pdbsum/8egt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8egt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/A0A1S6L1I6_9CAUD A0A1S6L1I6_9CAUD]  
[https://www.uniprot.org/uniprot/A0A1S6L1I6_9CAUD A0A1S6L1I6_9CAUD]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Staphylococcus epidermidis is an opportunistic pathogen of the human skin, often associated with infections of implanted medical devices. Staphylococcal picoviruses are a group of strictly lytic, short-tailed bacteriophages with compact genomes that are attractive candidates for therapeutic use. Here, we report the structure of the complete virion of S. epidermidis-infecting phage Andhra, determined using high-resolution cryo-electron microscopy, allowing atomic modeling of 11 capsid and tail proteins. The capsid is a T = 4 icosahedron containing a unique stabilizing capsid lining protein. The tail includes 12 trimers of a unique receptor binding protein (RBP), a lytic protein that also serves to anchor the RBPs to the tail stem, and a hexameric tail knob that acts as a gatekeeper for DNA ejection. Using structure prediction with AlphaFold, we identified the two proteins that comprise the tail tip heterooctamer. Our findings elucidate critical features for virion assembly, host recognition, and penetration.
Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra.,Hawkins NC, Kizziah JL, Hatoum-Aslan A, Dokland T Sci Adv. 2022 Dec 2;8(48):eade0459. doi: 10.1126/sciadv.ade0459. Epub 2022 Nov , 30. PMID:36449623<ref>PMID:36449623</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8egt" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Rakietenvirinae]]
[[Category: Rakietenvirinae]]

Latest revision as of 06:36, 19 June 2024

Capsid structure of Staphylococcus phage Andhra

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