1jch: Difference between revisions

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[[Image:1jch.~~gif~~|left|200px]]

[[Image:1jch.png|left|200px]]

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~~'''~~Crystal Structure of Colicin E3 in Complex with its Immunity Protein~~'''~~

===Crystal Structure of Colicin E3 in Complex with its Immunity Protein===

~~==Overview==~~

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~~Colicins kill E. coli by a process that involves binding to a surface receptor, entering the cell, and, finally, intoxicating it.~~ The ~~lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3~~, ~~reported here in a binary complex with its immunity protein (IP)~~, ~~reveals a Y-shaped molecule with~~ the ~~receptor binding domain forming a 100 A long stalk and~~ the ~~two globular heads of the translocation domain~~ (~~T) and the catalytic domain (C~~) ~~comprising the two arms. Active site residues are D510, H513, E517~~, ~~and R545. IP~~ is ~~buried between T and C. Rather than blocking the active site, IP prevents access of the active site to~~ the ~~ribosome~~.

The line below this paragraph, {{ABSTRACT_PUBMED_11741540}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11741540 is the PubMed ID number.

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==About this Structure==

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[[Category: The rnase domain is a six-stranded antiparallel beta-sheet. the immunity protein is a four-stranded antiparallel beta sheet flanked by 3 helices on one side of the sheet]]

[[Category: Translocation domain is a beta-jellyroll]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 21~~:03:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:01:21 2008''

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-[[Image:1jch.gif|left|200px]]
+{{Seed}}
+[[Image:1jch.png|left|200px]]
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 {{STRUCTURE_1jch|  PDB=1jch  |  SCENE=  }}
-'''Crystal Structure of Colicin E3 in Complex with its Immunity Protein'''
+===Crystal Structure of Colicin E3 in Complex with its Immunity Protein===
-==Overview==
+<!--
-Colicins kill E. coli by a process that involves binding to a surface receptor, entering the cell, and, finally, intoxicating it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3, reported here in a binary complex with its immunity protein (IP), reveals a Y-shaped molecule with the receptor binding domain forming a 100 A long stalk and the two globular heads of the translocation domain (T) and the catalytic domain (C) comprising the two arms. Active site residues are D510, H513, E517, and R545. IP is buried between T and C. Rather than blocking the active site, IP prevents access of the active site to the ribosome.
+The line below this paragraph, {{ABSTRACT_PUBMED_11741540}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11741540 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11741540}}
 ==About this Structure==
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 [[Category: The rnase domain is a six-stranded antiparallel beta-sheet. the immunity protein is a four-stranded antiparallel beta sheet flanked by 3 helices on one side of the sheet]]
 [[Category: Translocation domain is a beta-jellyroll]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:03:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 20:01:21 2008''