7zpm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7zpm is ~~ON HOLD~~

==Influenza A/H7N9 polymerase apo-protein dimer complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7zpm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Zhejiang/DTID-ZJU01/2013(H7N9)) Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZPM FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zpm OCA], [https://pdbe.org/7zpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zpm RCSB], [https://www.ebi.ac.uk/pdbsum/7zpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zpm ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/M9TI86_9INFA M9TI86_9INFA] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063][SAAS:SAAS00956500]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Cusack S]]

[[Category: Kouba T]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7zpm is ON HOLD
+==Influenza A/H7N9 polymerase apo-protein dimer complex==
+<StructureSection load='7zpm' size='340' side='right'caption='[[7zpm]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7zpm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Zhejiang/DTID-ZJU01/2013(H7N9)) Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZPM FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zpm OCA], [https://pdbe.org/7zpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zpm RCSB], [https://www.ebi.ac.uk/pdbsum/7zpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zpm ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/M9TI86_9INFA M9TI86_9INFA] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063][SAAS:SAAS00956500]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Cusack S]]
+[[Category: Kouba T]]