8f65: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8f65 is ~~ON HOLD until Paper Publication~~

==Crystal structure of VACV D13 in complex with BBL030900==

~~Authors~~: ~~Subedi~~, B.P., ~~Garriga~~, D., ~~Coulibaly~~, F.

== Structural highlights ==

<table><tr><td colspan='2'>[[8f65]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F65 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8F65 FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~VACV D13 in complex~~ with ~~BBL030900~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=QF6:8-methoxyquinolin-4-amine'>QF6</scene></td></tr>

[[Category: ~~Garriga, D~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8f65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f65 OCA], [https://pdbe.org/8f65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f65 RCSB], [https://www.ebi.ac.uk/pdbsum/8f65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f65 ProSAT]</td></tr>

[[Category: ~~Subedi, B.P~~]]

</table>

[[Category: ~~Coulibaly, F~~]]

== Function ==

[https://www.uniprot.org/uniprot/D13_VACCW D13_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Vaccinia virus]]

[[Category: Coulibaly F]]

[[Category: Garriga D]]

[[Category: Subedi BP]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8f65 is ON HOLD  until Paper Publication
+==Crystal structure of VACV D13 in complex with BBL030900==
+<StructureSection load='8f65' size='340' side='right'caption='[[8f65]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-Authors: Subedi, B.P., Garriga, D., Coulibaly, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8f65]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F65 FirstGlance]. <br>
-Description: Crystal structure of VACV D13 in complex with BBL030900
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=QF6:8-methoxyquinolin-4-amine'>QF6</scene></td></tr>
-[[Category: Garriga, D]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f65 OCA], [https://pdbe.org/8f65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f65 RCSB], [https://www.ebi.ac.uk/pdbsum/8f65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f65 ProSAT]</span></td></tr>
-[[Category: Subedi, B.P]]
+</table>
-[[Category: Coulibaly, F]]
+== Function ==
+[https://www.uniprot.org/uniprot/D13_VACCW D13_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Vaccinia virus]]
+[[Category: Coulibaly F]]
+[[Category: Garriga D]]
+[[Category: Subedi BP]]