1jdh: Difference between revisions

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[[Image:1jdh.gif|left|200px]]
{{Seed}}
[[Image:1jdh.png|left|200px]]


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{{STRUCTURE_1jdh|  PDB=1jdh  |  SCENE=  }}  
{{STRUCTURE_1jdh|  PDB=1jdh  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4'''
===CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4===




==Overview==
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Accumulation of the Wnt pathway effector beta-catenin is a hallmark of a number of cancers, including colon cancer. As beta-catenin accumulates in the cell, it forms a complex with Tcf family transcription factors and activates the transcription of several critical genes involved in cell proliferation. Because Tcf4 is the predominant Tcf factor present in colon cancer cells, drugs that specifically disrupt the beta-catenin-Tcf4 complex could be useful in treating colon cancers. Earlier structural and biochemical studies demonstrated that the central region of the beta-catenin binding domain of Tcf is essential for anchoring Tcf to beta-catenin via two conserved lysines in beta-catenin (called the charged 'buttons'). Here we report the crystal structure of a beta-catenin-Tcf4 complex at 2.0 A resolution. Our structural and mutagenesis studies show that Tcf4 docks specifically to beta-catenin using several distinct conformations in its essential central region. These conformations allow different glutamate residues in the central region of Tcf4 to form a salt bridge with the same critical charged button, Lys 312 of beta-catenin. We propose that this interaction may be the first event in beta-catenin-Tcf4 recognition.
The line below this paragraph, {{ABSTRACT_PUBMED_11713475}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11713475 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11713475}}


==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Tcf4]]
[[Category: Tcf4]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:05:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:04:21 2008''

Revision as of 17:04, 1 July 2008

File:1jdh.png

Template:STRUCTURE 1jdh

CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4

Template:ABSTRACT PUBMED 11713475

About this Structure

1JDH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Tcf4 can specifically recognize beta-catenin using alternative conformations., Graham TA, Ferkey DM, Mao F, Kimelman D, Xu W, Nat Struct Biol. 2001 Dec;8(12):1048-52. PMID:11713475

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