8fgx: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The~~ entry ~~8fgx~~ is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8fgx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FGX OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8FGX FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.62Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8fgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fgx OCA], [https://pdbe.org/8fgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fgx RCSB], [https://www.ebi.ac.uk/pdbsum/8fgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fgx ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.

== Function ==

[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Biris N]]

[[Category: Bista P]]

[[Category: Fuller JR]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8fgx is ON HOLD  until Paper Publication
+==Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein==
+<StructureSection load='8fgx' size='340' side='right'caption='[[8fgx]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8fgx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FGX FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fgx OCA], [https://pdbe.org/8fgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fgx RCSB], [https://www.ebi.ac.uk/pdbsum/8fgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fgx ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
+== Function ==
+[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Biris N]]
+[[Category: Bista P]]
+[[Category: Fuller JR]]