1jfp: Difference between revisions

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[[Image:1jfp.jpg|left|200px]]
{{Seed}}
[[Image:1jfp.png|left|200px]]


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{{STRUCTURE_1jfp|  PDB=1jfp  |  SCENE=  }}  
{{STRUCTURE_1jfp|  PDB=1jfp  |  SCENE=  }}  


'''Structure of bovine rhodopsin (dark adapted)'''
===Structure of bovine rhodopsin (dark adapted)===




==Overview==
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Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.
The line below this paragraph, {{ABSTRACT_PUBMED_11570894}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11570894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11570894}}


==About this Structure==
==About this Structure==
1JFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].  
1JFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].  


==Reference==
==Reference==
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[[Category: Yeagle, P L.]]
[[Category: Yeagle, P L.]]
[[Category: G-protein coupled receptor]]
[[Category: G-protein coupled receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:10:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:10:42 2008''
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