1ji7: Difference between revisions

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[[Image:1ji7.gif|left|200px]]
{{Seed}}
[[Image:1ji7.png|left|200px]]


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{{STRUCTURE_1ji7|  PDB=1ji7  |  SCENE=  }}  
{{STRUCTURE_1ji7|  PDB=1ji7  |  SCENE=  }}  


'''Crystal Structure of TEL SAM Polymer'''
===Crystal Structure of TEL SAM Polymer===




==Overview==
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TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.
The line below this paragraph, {{ABSTRACT_PUBMED_11483520}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11483520 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11483520}}


==Disease==
==Disease==
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[[Category: Tran, H H.]]
[[Category: Tran, H H.]]
[[Category: Helical polymer]]
[[Category: Helical polymer]]
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