Polycomb complex protein: Difference between revisions
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== Function == | == Function == | ||
'''Polycomb group ring finger protein 1''' (Pcgf1) is a link between Polycomb function and pluripotency <ref>PMID:26687479</ref>.<br /> | |||
'''Polycomb group ring finger protein 4''' (Pcgf4) or (BMI1) see below <ref>PMID:23523425</ref>.<br /> | |||
'''Polycomb group ring finger protein 5''' (Pcgf5) is regulator of gene expression and development <ref>PMID:29765032</ref>.<br /> | |||
'''Polycomb group ring finger protein 6''' (Pcgf6) has a role in safeguarding lineage decisions and in preventing aberrant expression of germ cell-related gens <ref>PMID:32482889</ref>.<br /> | |||
'''B-cell-specific Moloney leukemia virus insertion site 1''' (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development. | '''B-cell-specific Moloney leukemia virus insertion site 1''' (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development. | ||
