1jml: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:1jml.jpg|left|200px]]
{{Seed}}
[[Image:1jml.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jml|  PDB=1jml  |  SCENE=  }}  
{{STRUCTURE_1jml|  PDB=1jml  |  SCENE=  }}  


'''Conversion of Monomeric Protein L to an Obligate Dimer by Computational Protein Design'''
===Conversion of Monomeric Protein L to an Obligate Dimer by Computational Protein Design===




==Overview==
<!--  
Protein L consists of a single alpha-helix packed on a four-stranded beta-sheet formed by two symmetrically opposed beta-hairpins. We use a computer-based protein design procedure to stabilize a domain-swapped dimer of protein L in which the second beta-turn straightens and the C-terminal strand inserts into the beta-sheet of the partner. The designed obligate dimer contains three mutations (A52V, N53P, and G55A) and has a dissociation constant of approximately 700 pM, which is comparable to the dissociation constant of many naturally occurring protein dimers. The structure of the dimer has been determined by x-ray crystallography and is close to the in silico model.
The line below this paragraph, {{ABSTRACT_PUBMED_11526208}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11526208 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11526208}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Domain swapped dimer]]
[[Category: Domain swapped dimer]]
[[Category: Four stranded beta-sheet with central alpha helix]]
[[Category: Four stranded beta-sheet with central alpha helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:24:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:28:27 2008''
Retrieved from "https://proteopedia.org/1jml"