Syncytin: Difference between revisions
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Syncytin-1 has been correlated to several different kinds of cancers including breast cancer, carcinomas, and endometrial cancers. As mentioned above, the env gene of syncytin-1 can become activated and promote the production of cancerous cells <ref name='fossils'/>. Overexpression in syncytin-1 contributes to increased proliferation, metastasis, and the growth of tumors in individuals due to the methylation of DNA and the 5’LTR of the syncytin gene. The overmethylation contributes to the silencing of the tumor-suppressing gene <ref name= 'cancer'>Locke, W. J., Guanzon, D., Ma, C., Liew, Y. J., Duesing, K. R., Fung, K. Y. C., & Ross, J. P. (2019, November 14). DNA methylation cancer biomarkers: Translation to the clinic. Frontiers. Retrieved April 27, 2022, from https://www.frontiersin.org/articles/10.3389/fgene.2019.01150/full#:~:text=Hypermethylation%20can%20drive%20the%20silencing,et%20al.%2C%202015). </ref>. As a result, if both tumor suppressor genes in a cell contain a mutation, then the suppressor gene is deactivated. With the tumor suppressor gene losing function, cells may grow and divide unregulated, resulting in cancer. | Syncytin-1 has been correlated to several different kinds of cancers including breast cancer, carcinomas, and endometrial cancers. As mentioned above, the env gene of syncytin-1 can become activated and promote the production of cancerous cells <ref name='fossils'/>. Overexpression in syncytin-1 contributes to increased proliferation, metastasis, and the growth of tumors in individuals due to the methylation of DNA and the 5’LTR of the syncytin gene. The overmethylation contributes to the silencing of the tumor-suppressing gene <ref name= 'cancer'>Locke, W. J., Guanzon, D., Ma, C., Liew, Y. J., Duesing, K. R., Fung, K. Y. C., & Ross, J. P. (2019, November 14). DNA methylation cancer biomarkers: Translation to the clinic. Frontiers. Retrieved April 27, 2022, from https://www.frontiersin.org/articles/10.3389/fgene.2019.01150/full#:~:text=Hypermethylation%20can%20drive%20the%20silencing,et%20al.%2C%202015). </ref>. As a result, if both tumor suppressor genes in a cell contain a mutation, then the suppressor gene is deactivated. With the tumor suppressor gene losing function, cells may grow and divide unregulated, resulting in cancer. | ||
== | == Syncytiin 3D structures== | ||
[[5ha6]], [[6rx1]] – hSct1 fusion subunit 343-435 – human<br /> | |||
[[1y4m]], [[6rx3]] – hSct2 fusion subunit 375-468 <br /> | |||
[[7oix]] – hSct2 + MFSD2A – Cryo EM<br /> | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
