7trp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7trp is ~~ON HOLD until 2024~~-08-02

==Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7trp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRP FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUE:3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide'>IUE</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7trp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7trp OCA], [https://pdbe.org/7trp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7trp RCSB], [https://www.ebi.ac.uk/pdbsum/7trp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7trp ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Belousoff MJ]]

[[Category: Danev R]]

[[Category: Glukhova A]]

[[Category: Mobbs JI]]

[[Category: Sexton PM]]

[[Category: Thal DM]]

[[Category: Vuckovic Z]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7trp is ON HOLD  until 2024-08-02
+==Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298==
+<StructureSection load='7trp' size='340' side='right'caption='[[7trp]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7trp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRP FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUE:3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide'>IUE</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7trp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7trp OCA], [https://pdbe.org/7trp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7trp RCSB], [https://www.ebi.ac.uk/pdbsum/7trp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7trp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Belousoff MJ]]
+[[Category: Danev R]]
+[[Category: Glukhova A]]
+[[Category: Mobbs JI]]
+[[Category: Sexton PM]]
+[[Category: Thal DM]]
+[[Category: Vuckovic Z]]