7vrh: Difference between revisions
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==crystal structure of BRD2-BD1 in complex with guanosine analog== | |||
<StructureSection load='7vrh' size='340' side='right'caption='[[7vrh]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7vrh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VRH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AC2:9-HYROXYETHOXYMETHYLGUANINE'>AC2</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vrh OCA], [https://pdbe.org/7vrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vrh RCSB], [https://www.ebi.ac.uk/pdbsum/7vrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vrh ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arole A]] | |||
[[Category: Ashok S]] | |||
[[Category: Deshmukh P]] | |||
[[Category: Mathur S]] | |||
[[Category: Padmanabhan B]] | |||
Revision as of 11:16, 1 February 2023
crystal structure of BRD2-BD1 in complex with guanosine analog
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