1js6: Difference between revisions

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[[Image:1js6.gif|left|200px]]
{{Seed}}
[[Image:1js6.png|left|200px]]


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{{STRUCTURE_1js6|  PDB=1js6  |  SCENE=  }}  
{{STRUCTURE_1js6|  PDB=1js6  |  SCENE=  }}  


'''Crystal Structure of DOPA decarboxylase'''
===Crystal Structure of DOPA decarboxylase===




==Overview==
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DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. DDC has been implicated in a number of clinic disorders, including Parkinson's disease and hypertension. Peripheral inhibitors of DDC are currently used to treat these diseases. We present the crystal structures of ligand-free DDC and its complex with the anti-Parkinson drug carbiDOPA. The inhibitor is bound to the enzyme by forming a hydrazone linkage with the cofactor, and its catechol ring is deeply buried in the active site cleft. The structures provide the molecular basis for the development of new inhibitors of DDC with better pharmacological characteristics.
The line below this paragraph, {{ABSTRACT_PUBMED_11685243}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11685243 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11685243}}


==About this Structure==
==About this Structure==
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[[Category: Parkinson's disease]]
[[Category: Parkinson's disease]]
[[Category: Vitamin b6]]
[[Category: Vitamin b6]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:49:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:43:27 2008''
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