1jsy: Difference between revisions

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[[Image:1jsy.gif|left|200px]]
{{Seed}}
[[Image:1jsy.png|left|200px]]


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{{STRUCTURE_1jsy|  PDB=1jsy  |  SCENE=  }}  
{{STRUCTURE_1jsy|  PDB=1jsy  |  SCENE=  }}  


'''Crystal structure of bovine arrestin-2'''
===Crystal structure of bovine arrestin-2===




==Overview==
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Arrestin binding to activated, phosphorylated G protein-coupled receptors (GPCRs) represents a critical step in regulation of light- and hormone-dependent signaling. Nonvisual arrestins, such as arrestin-2, interact with multiple proteins for the purpose of propagating and terminating signaling events. Using a combination of X-ray crystallography, molecular modeling, mutagenesis, and binding analysis, we reveal structural features of arrestin-2 that may enable simultaneous binding to phosphorylated receptor, SH3 domains, phosphoinositides, and beta-adaptin. The structure of full-length arrestin-2 thus provides a uniquely oriented scaffold for assembly of multiple, diverse molecules involved in GPCR signal transduction.
The line below this paragraph, {{ABSTRACT_PUBMED_11876640}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11876640 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11876640}}


==About this Structure==
==About this Structure==
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[[Category: Endocytosis]]
[[Category: Endocytosis]]
[[Category: Nonvisual arrestin]]
[[Category: Nonvisual arrestin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:52:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:45:14 2008''
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