1jtp: Difference between revisions

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[[Image:1jtp.gif|left|200px]]
{{Seed}}
[[Image:1jtp.png|left|200px]]


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{{STRUCTURE_1jtp|  PDB=1jtp  |  SCENE=  }}  
{{STRUCTURE_1jtp|  PDB=1jtp  |  SCENE=  }}  


'''Degenerate interfaces in antigen-antibody complexes'''
===Degenerate interfaces in antigen-antibody complexes===




==Overview==
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In most of the work dealing with the analysis of protein-protein interfaces, a single X-ray structure is available or selected, and implicitly it is assumed that this structure corresponds to the optimal complex for this pair of proteins. However, we have found a degenerate interface in a high-affinity antibody-antigen complex: the two independent complexes of the camel variable domain antibody fragment cAb-Lys3 and its antigen hen egg white lysozyme present in the asymmetric unit of our crystals show a difference in relative orientation between antibody and antigen, leading to important differences at the protein-protein interface. A third cAb-Lys3-hen lysozyme complex in a different crystal form adopts yet another relative orientation. Our results show that protein-protein interface characteristics can vary significantly between different specimens of the same high-affinity antibody-protein antigen complex. Consideration should be given to this type of observation when trying to establish general protein-protein interface characteristics.
The line below this paragraph, {{ABSTRACT_PUBMED_11676532}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11676532 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11676532}}


==About this Structure==
==About this Structure==
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[[Category: Interface]]
[[Category: Interface]]
[[Category: Vhh]]
[[Category: Vhh]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:54:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:47:28 2008''

Revision as of 17:47, 1 July 2008

File:1jtp.png

Template:STRUCTURE 1jtp

Degenerate interfaces in antigen-antibody complexes

Template:ABSTRACT PUBMED 11676532

About this Structure

1JTP is a Protein complex structure of sequences from Camelus dromedarius and Meleagris gallopavo. Full crystallographic information is available from OCA.

Reference

Degenerate interfaces in antigen-antibody complexes., Decanniere K, Transue TR, Desmyter A, Maes D, Muyldermans S, Wyns L, J Mol Biol. 2001 Oct 26;313(3):473-8. PMID:11676532

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